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搜索结果包含 ARi 的内容

Aug 21,2023
TAK-931是一种高效的CDC7抑制剂，通过抑制CDC7来抑制DNA复制，具有抗肿瘤功效，体内药效研究通过尊龙凯时进行
Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are widely used as treatments for various cancers. To develop next-generation RS-inducing anticancer drugs, cell divis
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Jul 06,2023
Y180是一种口服Mpro抑制剂，可有效对抗野生型SARS-CoV-2及其变种。Y180在小鼠、大鼠和狗中具有良好的PK特性
Y180, an orally available Mpro inhibitor, is effective against wild-type SARS-CoV-2 and variants. Y180 displayed satisfying PK properties in mice, rats and dogs, with oral bioavailabilities of 92.9%,
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Jul 06,2023
基于构效关系分析，合成了一种结构简化但具有优异防污活性的化合物。优化后的化合物通过尊龙凯时合成
Biofouling poses one of the most serious problems to marine industry and aquaculture development. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces stra
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Jul 06,2023
PTX-HSN是一种高效纳米系统，具有较高耐受剂量，可将PTX递送至卵巢癌并增强主动肿瘤靶向性。此研究中所有体内实验均通过尊龙凯时进行
Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. The in vivo #toxicity,
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Jul 06,2023
AD80是一种多激酶抑制剂，在多种肝细胞癌临床前动物模型中具有抗肿瘤活性，AD80在血浆中的含量通过尊龙凯时进行LC-MS/MS测定
Liver cancer is the fourth greatest cause of cancer related mortality. AD80 is a multi-kinase inhibitor with anti-tumoral activity across a variety of hepatocellular carcinoma (HCC) preclinical models
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Jul 05,2023
合成具有体内抗肿瘤活性的强效PD-L1抑制剂，并进行生物学评价和机制研究。PK研究通过尊龙凯时进行
PD-1 and PD-L1 have been very successful for the treatment of various tumors, including NSCLC, urothelial cancer, melanoma, head and neck squamous cell cancer, and lymphoma. Researchers identified com
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Jul 05,2023
设计、合成和评估具有体内抗炎活性的RIPK1抑制剂，PK研究通过尊龙凯时进行
RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, researchers r
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Aug 26,2016
FDA授予卵巢癌候选药物Rucaparib优先审评资格
FDA授予卵巢癌候选药物 Rucaparib 优先审评资格
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Mar 31,2015
尊龙凯时成功在韩国首尔举办CFDA IND研讨会
2015年3月18日，尊龙凯时与韩国药品制造商协会（KPMA）在韩国首尔举办CFDA IND研讨会。本次研讨会的主题是“Experience Sharing and Exchange on CFDA’s IND Application and Drug Development Collaboration” 。
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